Health Library/ED Treatment Options
Sexual Health

ED Treatment When Pills Don't Work: What's Next?

Viagra and Cialis fail for up to 40% of men. Here are proven alternatives—including treatments with a 98% success rate.*

By Dr. Carlos Feliciano, MD
December 18, 2024
7 min read

If you've tried Viagra, Cialis, or other PDE5 inhibitors without success, you're not alone. Studies show that oral ED medications fail to produce adequate results in 30-40% of men. But that doesn't mean there aren't solutions.

Why ED Pills Fail for Some Men

Severe Vascular Disease

Diabetes or heart disease can damage blood vessels beyond what oral medications can overcome.

Nerve Damage

Prostate surgery or pelvic trauma can affect nerve signals needed for pills to work.

Medication Interactions

Some blood pressure or antidepressant medications can interfere with ED medication effectiveness.

Psychological Factors

Performance anxiety after failed attempts can create a cycle where medication seems not to work.

Proven Alternatives When Pills Fail

Penile Injection Therapy

98%* Success

The most effective option when pills fail. A small injection produces an erection within 5-10 minutes.

Advantages

Highest success rate of any ED treatment
Works regardless of nerve or vascular damage
Reliable, predictable results

Considerations

Requires self-injection
Must be used in-office first for dosing

Low-Intensity Shockwave Therapy

Varies Success

Non-invasive treatment using acoustic waves to improve blood flow and stimulate tissue regeneration.

Advantages

Non-invasive, no medications
May improve natural function long-term
No downtime or side effects

Considerations

Requires multiple sessions (6-12)
Results take 2-4 weeks to appear

PRP Therapy (Eros® Procedure)

Emerging Success

Uses your own platelet-rich plasma to promote tissue regeneration and improve erectile function.

Advantages

Uses your own blood (autologous)
May improve sensitivity
Minimal downtime

Considerations

Newer treatment with less long-term data
Results vary by individual

Our Approach

We find out WHY you're experiencing ED. We check hormone levels, cardiovascular health, and other factors that pills can't address. Most men are surprised at how easy and painless injection therapy actually is.

*98% Success Rate: Based on internal clinical study of penile injection therapy patients achieving erections sufficient for intercourse.

Ready for ED Treatment That Works?

Schedule a confidential consultation. We'll find a solution that works for you.