Medical Weight Loss: Semaglutide, Tirzepatide & GLP-1 Guide
Medical weight loss using GLP-1 medications like semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound) produces average weight loss of 15-20% of body weight—significantly more effective than diet and exercise alone (typically 5-7%). These injectable medications work by reducing appetite, increasing satiety, and slowing gastric emptying. Clinical trials show semaglutide produces 15% average weight loss and tirzepatide produces 20%+ average weight loss over 68-72 weeks.
How Semaglutide and Tirzepatide Work
GLP-1 medications mimic natural hormones that regulate appetite and blood sugar:
Appetite Suppression
Signals brain's hunger center to reduce appetite
Increased Satiety
Feel full faster and stay satisfied longer
Slowed Gastric Emptying
Food stays in stomach longer
Blood Sugar Regulation
Improves insulin sensitivity
Comparing Weight Loss Medications
| Medication | Brand Names | Avg Weight Loss | Mechanism | Monthly Cost |
|---|---|---|---|---|
| Semaglutide | Wegovy, Ozempic | 15% | GLP-1 | $399-500 |
| Tirzepatide | Mounjaro, Zepbound | 20%+ | GLP-1 + GIP | $499-600 |
| Liraglutide | Saxenda | 8% | GLP-1 | $400-500 |
| Phentermine | Adipex | 5-7% | Stimulant | $50-100 |
| Diet/Exercise | N/A | 5-7% | Lifestyle | N/A |
What Results Can I Expect?
Semaglutide (Wegovy)
- Average weight loss: 15% of body weight
- 200 lb person loses approximately 30 lbs
- One-third of patients lose 20%+
Tirzepatide (Mounjaro/Zepbound)
- Average weight loss: 20%+ of body weight
- 200 lb person loses approximately 40+ lbs
- Over half of patients lose 20%+
Results Timeline
What to Expect: Starting Medical Weight Loss
Initial Consultation
Review health history and goals
Medical Evaluation
Physical exam, lab work, BMI assessment
Medication Selection
Choose semaglutide or tirzepatide
Dose Titration
Start low, gradually increase over 4-8 weeks
Weekly Injections
Self-administer at home
Monthly Check-ins
Monitor progress, adjust dosing
Maintenance
Long-term strategy as you approach goal
Who Qualifies for Medical Weight Loss?
Medical weight loss is appropriate for:
- BMI 30+ (obese)
- BMI 27+ with weight-related condition (diabetes, high blood pressure)
- Those who haven't achieved goals with diet/exercise alone
Not recommended for:
- • History of medullary thyroid cancer or MEN2
- • History of pancreatitis
- • Pregnant or planning pregnancy
Semaglutide and Tirzepatide Side Effects
Common side effects (usually temporary):
Pro tip: Starting at low doses and gradually increasing minimizes side effects.
Frequently Asked Questions
How much weight can I lose on semaglutide?
Clinical trials show average weight loss of 15% with semaglutide. A 200-pound person loses approximately 30 pounds. One-third of patients lose 20% or more.
Is semaglutide the same as Ozempic?
Semaglutide is the active ingredient in both Ozempic and Wegovy. Ozempic is FDA-approved for diabetes, Wegovy for weight loss. They're chemically identical.
How much does medical weight loss cost?
Semaglutide costs $399-500/month, tirzepatide $499-600/month at our clinic. We use compounded medications less expensive than brand-name Wegovy ($1,300+/month).
Do I have to take semaglutide forever?
Studies show weight regain of approximately two-thirds within one year of stopping. Many patients transition to maintenance doses or develop sustainable habits.
What's the difference between semaglutide and tirzepatide?
Semaglutide is a GLP-1 agonist, tirzepatide is dual GLP-1/GIP agonist. Tirzepatide produces greater weight loss (20%+ vs 15%) but costs more.
How fast does semaglutide work?
Appetite reduction begins within the first week. Most see 5-8% weight loss within 1-2 months. Maximum results by 12-16 months.
Can men take semaglutide for weight loss?
Yes, semaglutide is equally effective for men and women. Men may see faster initial results due to higher baseline metabolic rates.
Ready to Start Your Weight Loss Journey?
Find out if semaglutide or tirzepatide is right for you. Schedule your free consultation and get a personalized weight loss plan.
Medical Disclaimer: Individual weight loss results vary based on starting weight, adherence to treatment, diet, and exercise. GLP-1 medications require medical evaluation. Consult with our medical team to determine if medical weight loss is right for you.